• two basal-like subtypes, which they call BL1 and BL2; these are correlated with cell cycle and DNA damage response genes
• two "mesanchymal" types, which they call M and MSL; these correlate to genes involved in cell differentiation and growth factor pathways
• an immunomodularity type, which they call IM, correlated with immune system genes
• a luminal group,which they call LAR, correlated with androgen, or the male sex hormone.
The groups respond differently to chemotherapy:
• BL1 and BL2 respond to cisplatin
• M and MSL respond to dastanib and an experimental drug NVP-BEZ235
• LAR respond to biculatamide
Read the entire news release from Vanderbilt here.