Patients with later stage nonmetastatic triple receptor-negative breast tumors have a significantly increased early incidence of brain metastase, according to a retrospective study published in the Annals of Oncology. Researchers studied 679 patients with nonmetastatic triple receptor-negative breast cancer diagnosed from 1980 to 2006. Other factors—race, age, menopausal status, and grade of disease—were not significantly associated with the development of brain metastases. Of the 679:
• 87.3 percent had chemo either before or after surgery.
• 89.5 % of these had stage 3 disease.
• Median survival for all patients who developed brain metastases was 2.9 months.
• Median survival for patients who developed brain metastases as the first site of recurrence was 5.8 months.
Call me a Pollyanna, but I can’t help pointing out that this means that more than 90 percent of those studied DID NOT get brain metastases.
SOURCE: Dawood, S., Broglio, K., Esteva, F. J., Yang, W., Kau, S. . W., Islam, R., Albarracin, C., Yu, T. K., Green, M., Hortobagyi, G. N., and Gonzalez-Angulo, A. M. Survival among women with triple receptor-negative breast cancer and brain metastases. Annals of Oncology, 20(4):621-627.
3 comments:
Pat,
Very interesting study. Thanks for bringing it to our attention! Pollyanna or not, those numbers are encouraging...now to find something to eliminate TN forever!
LOL! You are so right. I was immediately looking at it from the negative perspective!
Kim and Jojo: I am so glad you both picked up on my Pollyanna statement. Sometimes I wonder if I should add that sort of editorial comment--but it seems that the good news does get buried in medical reports. We need all the good news we can get--and docs are so focused on the problem that they sometimes cannot see that reality. Pat
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