Which models are most
effective in determining a woman’s five-year risk of breast and ovarian cancer?
Research published in the November 5, 2012 edition of Breast Cancer
Research indicates that the International Breast Cancer Intervention Study (IBIS) might be the most effective and
could be used effectively even for women without risk factors.
Researchers compared
the IBIS model with the Breast Cancer Risk
Assessment Tool.
The IBIS model, also called Tyrer Cuzick
model, is generally used for patients with above-average risk based on extended
family history and genetic makeup.
BCRAT,
also called the Gail model, is used for women with average risk based on family
history and genetic makeup.
They concluded that the IBIS
model offers the most opportunity for risk assessment, but suggested that it
might be combined with other risk assessment tools, including those that test
for the BRCA 1 and 2 genetic mutations.
That is, the best approach is to look at a multitude of factors
including genes and family history.
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