Tuesday, November 6, 2012

Weighing Family History Plus Genes Offers Best Assessment of Breast Cancer and Ovarian Cancer Risk

Which models are most effective in determining a woman’s five-year risk of breast and ovarian cancer? Research published in the November 5, 2012 edition of Breast Cancer Research indicates that the International Breast Cancer Intervention Study (IBIS) might be the most effective and could be used effectively even for women without risk factors.

Researchers compared the IBIS model with the Breast Cancer Risk Assessment Tool.
The IBIS model, also called Tyrer Cuzick model, is generally used for patients with above-average risk based on extended family history and genetic makeup.
BCRAT, also called the Gail model, is used for women with average risk based on family history and genetic makeup.
They concluded that the IBIS model offers the most opportunity for risk assessment, but suggested that it might be combined with other risk assessment tools, including those that test for the BRCA 1 and 2 genetic mutations.  That is, the best approach is to look at a multitude of factors including genes and family history.

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